Malaria: New Chemotherapeutic Peroxide Drugs

Author(s): Kristina Borstnik, Ik-hyeon Paik, Gary H. Posner.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 6 , 2002

Abstract:

Chemical insights into artemisinins biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.

Keywords: malaria, chemotherapeutic peroxide drugs, artemisinin biological mechanism, malaria chemotherapy, antimalarial peroxide artemisinin, anopheline mosquitoes, host bloodstream, aggregation, acute encephalopathy

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Article Details

VOLUME: 2
ISSUE: 6
Year: 2002
Page: [573 - 583]
Pages: 11
DOI: 10.2174/1389557023405620
Price: $58