Peptidomimetics and Peptide Backbone Modifications

Author(s): Jung-Mo Ahn, Nicholas A. Boyle, Mary T. MacDonald, Kim D. Janda.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 5 , 2002

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The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.

Keywords: peptidomimetics, backbone modifications, hydrophobicity of pseudopeptides, enzymatic stability, amino acids, human, immunodeficiency

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Article Details

Year: 2002
Page: [463 - 473]
Pages: 11
DOI: 10.2174/1389557023405828
Price: $58

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