Design, Synthesis, and Application of Peptide Secondary Structure Mimetics

Author(s): Masakatsu Eguchi , Michael Kahn .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 5 , 2002

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The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent developments in this field.

Keywords: secondary structure mimetics, peptidomimetic approach, proteinaceous leads, tetrapeptide units, privileged template, reverseturn mimetics, solid phase synthesis

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Article Details

Year: 2002
Page: [447 - 462]
Pages: 16
DOI: 10.2174/1389557023405783
Price: $58

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