How Do Channel- and Pore-Forming Helical Peptides Interact with Lipid Membranes and How does this Account for their Antimicrobial Activity?

Author(s): Herve Duclohier.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 4 , 2002

Abstract:

Animals and plants defend themselves against pathogenic micro-organisms by the rapid mobilization of polycationic helical amphipathic peptides. Interactions with membranes induce optimal orientation and mutual structural changes, allowing for example to form transbilayer ion channels or pores whose properties are compared in this review. Physicochemical studies of peptide-lipid interactions provide attractive approaches for drug design.

Keywords: channel-forming peptides, poe-forming peptides, defense peptide, amphipathicity, lipid composition, cellular targets, planar lipid bilayers

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2002
Page: [331 - 342]
Pages: 12
DOI: 10.2174/1389557023405963
Price: $58

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