Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease

Author(s): Felix Hernandez, Filip Lim, Jose J. Lucas, Concepcion Perez-Martin, Franscisco Moreno, Jesus Avila.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 1 , 2002

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Abstract:

The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease.

Keywords: Tau Pathology, Alzheimers Disease, tau hyperphosphorylation

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2002
Page: [51 - 58]
Pages: 8
DOI: 10.2174/1389557023406557

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