Cholinergic Drugs in Pharmacotherapy of Alzheimers Disease

Author(s): Pelayo Camps, Diego Munoz-Torrero.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 1 , 2002

Abstract:

The cholinergic hypothesis of Alzheimers disease has spurred the development of numerous structural classes of compounds with different pharmacological profiles aimed at increasing central cholinergic neurotransmission, thus providing a symptomatic treatment for this disease. Indeed, the only drugs currently approved for the treatment of Alzheimers disease are cholinomimetics with the pharmacological profile of acetylcholinesterase inhibitors. Recent evidence of a potential disease modifying role of acetylcholinesterase inhibitors and M1 muscarinic agonists have led to a revival of this approach, which might be considered as more than a symptomatic treatment.

Keywords: Cholinergic Drugs, Alzheimers disease, muscarinic agonists, acetylcholine (ACh), Potassium Channel Blockers, Aminoacridines, N-Benzylpiperidines, xanomeline, muscarine

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2002
Page: [11 - 25]
Pages: 15
DOI: 10.2174/1389557023406638