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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 2
ISSUE: 1
DOI: 10.2174/1389557023406638









Cholinergic Drugs in Pharmacotherapy of Alzheimers Disease

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Author(s): Pelayo Camps and Diego Munoz-Torrero
Pages 11-25 (15)
Abstract:
The cholinergic hypothesis of Alzheimers disease has spurred the development of numerous structural classes of compounds with different pharmacological profiles aimed at increasing central cholinergic neurotransmission, thus providing a symptomatic treatment for this disease. Indeed, the only drugs currently approved for the treatment of Alzheimers disease are cholinomimetics with the pharmacological profile of acetylcholinesterase inhibitors. Recent evidence of a potential disease modifying role of acetylcholinesterase inhibitors and M1 muscarinic agonists have led to a revival of this approach, which might be considered as more than a symptomatic treatment.
Keywords:
Cholinergic Drugs, Alzheimers disease, muscarinic agonists, acetylcholine (ACh), Potassium Channel Blockers, Aminoacridines, N-Benzylpiperidines, xanomeline, muscarine
Affiliation:
Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av Diagonal 643, E-08028, Barcelona, Spain.