Mini-Reviews in Medicinal Chemistry


Cholinergic Drugs in Pharmacotherapy of Alzheimers Disease

Author(s): Pelayo Camps and Diego Munoz-Torrero

Affiliation: Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av Diagonal 643, E-08028, Barcelona, Spain.


The cholinergic hypothesis of Alzheimers disease has spurred the development of numerous structural classes of compounds with different pharmacological profiles aimed at increasing central cholinergic neurotransmission, thus providing a symptomatic treatment for this disease. Indeed, the only drugs currently approved for the treatment of Alzheimers disease are cholinomimetics with the pharmacological profile of acetylcholinesterase inhibitors. Recent evidence of a potential disease modifying role of acetylcholinesterase inhibitors and M1 muscarinic agonists have led to a revival of this approach, which might be considered as more than a symptomatic treatment.

Keywords: Cholinergic Drugs, Alzheimers disease, muscarinic agonists, acetylcholine (ACh), Potassium Channel Blockers, Aminoacridines, N-Benzylpiperidines, xanomeline, muscarine

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Article Details

Page: [11 - 25]
Pages: 15
DOI: 10.2174/1389557023406638