Abstract
In the past decade major advances have been made towards understanding the mechanisms by which polytopic membrane proteins fold and assemble in cellular membranes. In eukaryotes, this process is mediated by a complex set of machinery in the endoplasmic reticulum (ER) that facilitates translocation of peptide loops across and integration of hydrophobic helices into the lipid bilayer. Studies evaluating the biogenesis of P-glycoprotein (P-gp) have been at the forefront of this rapidly expanding field. They have revealed a fascinating although sometimes confusing picture that has challenged our notions about general mechanisms of polytopic protein assembly and questioned specific predictions about the details and uniqueness of P-gp transmembrane topology. This review will attempt to summarize and consolidate our current knowledge of the sequence of events that gives rise to P-gp topology in the ER compartment and the implications of these events for polytopic protein biogenesis and function.
Keywords: P-glycoprotein, Cellular Membranes, TOPOLOGY, BIOGENESIS
Current Protein & Peptide Science
Title: Molecular Mechanism of P-glycoprotein Assembly into Cellular Membranes
Volume: 3 Issue: 5
Author(s): Victoria Anthony and William R. Skach
Affiliation:
Keywords: P-glycoprotein, Cellular Membranes, TOPOLOGY, BIOGENESIS
Abstract: In the past decade major advances have been made towards understanding the mechanisms by which polytopic membrane proteins fold and assemble in cellular membranes. In eukaryotes, this process is mediated by a complex set of machinery in the endoplasmic reticulum (ER) that facilitates translocation of peptide loops across and integration of hydrophobic helices into the lipid bilayer. Studies evaluating the biogenesis of P-glycoprotein (P-gp) have been at the forefront of this rapidly expanding field. They have revealed a fascinating although sometimes confusing picture that has challenged our notions about general mechanisms of polytopic protein assembly and questioned specific predictions about the details and uniqueness of P-gp transmembrane topology. This review will attempt to summarize and consolidate our current knowledge of the sequence of events that gives rise to P-gp topology in the ER compartment and the implications of these events for polytopic protein biogenesis and function.
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Cite this article as:
Anthony Victoria and Skach R. William, Molecular Mechanism of P-glycoprotein Assembly into Cellular Membranes, Current Protein & Peptide Science 2002; 3 (5) . https://dx.doi.org/10.2174/1389203023380503
DOI https://dx.doi.org/10.2174/1389203023380503 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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