cycloSal-d4TMP Pronucleotides-Structural Variations, Mechanistic Insights and Antiviral Activity

Author(s): Chris Meier, Jurgen Renze, Christian Ducho, Jan Balzarini.

Journal Name: Current Topics in Medicinal Chemistry

Volume 2 , Issue 10 , 2002

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Pronucleotides represent a promising alternative to improve the biological activity of nucleoside analogues against different viral diseases. The basic idea is to achieve nucleotide delivery into cells, bypassing limitations with intracellular formation of nucleotides from their nucleoside precursors. The cycloSal-concept is one of several pronucleotide systems reported so far. For the nucleoside analogue d4T, the cycloSal-approach improved antiviral potency. The basic idea, chemistry, different structural modifications and their effects on the antiviral potency of the cycloSal-d4TMP triesters have been discussed in this review.

Keywords: pronucleotides-structural variations, biological activity of nucleoside analogues, enzymatically triggered pronucleotides, hplc-analyzed studies, enzymatic degradation

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Article Details

Year: 2002
Page: [1111 - 1121]
Pages: 11
DOI: 10.2174/1568026023393183
Price: $58

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