Crystallization and Preliminary X-Ray Diffraction Analysis of FKBP12 Complexed with a Novel Neurotrophic Ligand

Title: Crystallization and Preliminary X-Ray Diffraction Analysis of FKBP12 Complexed with a Novel Neurotrophic Ligand

Volume: 9 Issue: 5

Author(s): Pengyun Li, Liwei Wang, Yi Ding, Beili Wu, Cuiling Shu, Aihua Nie, Song Li, Beifen Shen and Zihe Rao

Affiliation:

Keywords: FKBP12, (3R)-4-(p-Toluenesulfonyl)-1, 4-thiazane-3-carboxylic acid- L-Leucine, 000308, crystallization, ligand, complex, neurotrophic, X-ray

Abstract: A novel neurotrophic ligand, (3R)-4-(p-Toluenesulfonyl)-1,4-thiazane-3-carboxylic acid-L-Leucine ethyl ester, has been complexed with FKBP12 and crystallized using the hanging-drop vapor-diffusion method. Crystals belong to P2 1 space group, with unit cell parameters a=41.2, b=29.6, c=41.5Å, β=114.0 . The crystals diffract to 1.8 Å resolution limit.

Cite this article as:

Li Pengyun, Wang Liwei, Ding Yi, Wu Beili, Shu Cuiling, Nie Aihua, Li Song, Shen Beifen and Rao Zihe, Crystallization and Preliminary X-Ray Diffraction Analysis of FKBP12 Complexed with a Novel Neurotrophic Ligand, Protein & Peptide Letters 2002; 9 (5) . https://dx.doi.org/10.2174/0929866023408517