A Synthetic Strategy for on-Resin Amino Acid Specific Multiple Fatty Acid Acylation of Peptides

Author(s): Avaronnan Harishchandran, Bhattaram Pallavi, Ramakrishnan Nagaraj.

Journal Name: Protein & Peptide Letters

Volume 9 , Issue 5 , 2002

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Abstract:

Covalent modification with fatty acids is observed in several proteins that play crucial roles in cellular physiology. In this paper, a convenient method for the generation of multiple fatty acylated synthetic peptides is described. Peptides were synthesized using solid phase procedures with fluorenylmethoxycarbonyl α-amino protected amino acids. Acetamidomethyl protected cysteines were employed. The thiol protecting group was selectively deprotected and acylation was carried out on the resin-bound peptides. The strategy described in this report is applicable to any peptide sequence.

Keywords: acylation, myristic acid, palmitic acid, multiple acylation, peptide synthesis

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2002
Page: [411 - 417]
Pages: 7
DOI: 10.2174/0929866023408571
Price: $58

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