The use of Dodt as a Non-Malodorous Scavenger in Fmoc-Based Peptide Synthesis

Author(s): A. Teixeira, W. E. Benckhuijsen, P. E. de Koning, A. R.P.M. Valentijn, J. W. Drijfhout.

Journal Name: Protein & Peptide Letters

Volume 9 , Issue 5 , 2002

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We have synthesized a random group of peptides and performed cleavages using various cleavage cocktails including 3,6-dioxa-1,8-octanedithiol (DODT). Purity of the peptides was compared to that obtained with standard protocols for cleavage using RP-HPLC and Maldi-Tof mass spectrometry. We show that stinking thiols can be replaced by the almost odourless (DODT) without negatively affecting the purity of the end product.

Keywords: NON-MALODOROUS, SCAVENGER, FMOC-BASED PEPTIDE, Peptide synthesis, thiols, DODT, 3,6-dioxa -1,8-octa ne dithiol

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Article Details

Year: 2002
Page: [379 - 385]
Pages: 7
DOI: 10.2174/0929866023408481
Price: $58

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