We have synthesized a random group of peptides and performed cleavages using various cleavage cocktails including 3,6-dioxa-1,8-octanedithiol (DODT). Purity of the peptides was compared to that obtained with standard protocols for cleavage using RP-HPLC and Maldi-Tof mass spectrometry. We show that stinking thiols can be replaced by the almost odourless (DODT) without negatively affecting the purity of the end product.
Keywords: NON-MALODOROUS, SCAVENGER, FMOC-BASED PEPTIDE, Peptide synthesis, thiols, DODT, 3,6-dioxa -1,8-octa ne dithiol
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