Abstract
Porphyromonas gingivalis is a black-pigmented anaerobic gram-negative bacterium that is a major pathogen of chronic adult periodontitis, an inflammatory disease of toothsupporting tissues. P. gingivalis possesses a number of potential virulence factors. Among them, cell-surface-associated and secreted proteinases such as Arg-gingipain and Lys-gingipain have received much attention because they can degrade various host proteins and cause inflammation. Molecular genetic analysis is extremely powerful to evaluate the significance of each virulence factor in a pathogenic microorganism. This review will describe the introduction of molecular genetics to analysis of pathogenesis of P. gingivalis and the findings that have been obtained using knockout mutants of various potential virulence factors, especially proteinases.
Keywords: molecular genetics, porphyromonas gingivalis, gingipains, virulence factors, chronic adult periodontitis, toothsupporting tissues, arg-gingipain, lys-gingipain, proteinases
Current Protein & Peptide Science
Title: Molecular Genetics of Porphyromonas gingivalis: Gingipains and other Virulence Factors
Volume: 4 Issue: 6
Author(s): K. Nakayama
Affiliation:
Keywords: molecular genetics, porphyromonas gingivalis, gingipains, virulence factors, chronic adult periodontitis, toothsupporting tissues, arg-gingipain, lys-gingipain, proteinases
Abstract: Porphyromonas gingivalis is a black-pigmented anaerobic gram-negative bacterium that is a major pathogen of chronic adult periodontitis, an inflammatory disease of toothsupporting tissues. P. gingivalis possesses a number of potential virulence factors. Among them, cell-surface-associated and secreted proteinases such as Arg-gingipain and Lys-gingipain have received much attention because they can degrade various host proteins and cause inflammation. Molecular genetic analysis is extremely powerful to evaluate the significance of each virulence factor in a pathogenic microorganism. This review will describe the introduction of molecular genetics to analysis of pathogenesis of P. gingivalis and the findings that have been obtained using knockout mutants of various potential virulence factors, especially proteinases.
Export Options
About this article
Cite this article as:
Nakayama K., Molecular Genetics of Porphyromonas gingivalis: Gingipains and other Virulence Factors, Current Protein & Peptide Science 2003; 4 (6) . https://dx.doi.org/10.2174/1389203033486983
DOI https://dx.doi.org/10.2174/1389203033486983 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial (Hot Topic: Pharmacological and Molecular Targets in Cellular Redox Status Maintenance)
Current Pharmaceutical Design Meet Our Editorial Board Member
Recent Patents on Drug Delivery & Formulation Antiproliferative Properties of 7,8-Ethylene Diamine Chelator-Lipophilic Fluoroquinolone Derivatives Against Colorectal Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Poly(ADP-Ribose) Polymerase Inhibitors: New Pharmacological Functions and Potential Clinical Implications
Current Pharmaceutical Design Update on ICOS: A Possible Target for Turning-Off Autoimmunity
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Self-Assembling Peptide Nanofibrous Scaffolds for Tissue Engineering: Novel Approaches and Strategies for Effective Functional Regeneration
Current Protein & Peptide Science Excessive Matrix Metalloproteinase Activity in Diabetes: Inhibition by Tetracycline Analogues with Zinc Reactivity
Current Medicinal Chemistry Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response
Recent Patents on CNS Drug Discovery (Discontinued) A Review of Techniques for Gene Therapy in Bone Healing
Current Stem Cell Research & Therapy In Search of Novel and Therapeutically Significant Melatoninergic Ligands
Recent Patents on CNS Drug Discovery (Discontinued) The Current and Future Therapies for Human Osteosarcoma
Current Cancer Therapy Reviews Fungal Biofilms and Antimycotics
Current Drug Targets <I>Grewia asiatica</I> Mucilage: A Smart Gelling Polymeric Material for Pharmaceutical Applications <i>In Vitro</i> Studies
Current Materials Science Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers
Combinatorial Chemistry & High Throughput Screening The Proteasome as a Therapeutic Target for Lung Fibrosis
Current Enzyme Inhibition Lactoferrin: A Biologically Active Molecule for Bone Regeneration
Current Medicinal Chemistry Toll Like Receptors in Copd and Periodontal Disease-A Mini Review
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Quantitative Determination of Quercitrin Levels in Rat Plasma Using UHPLC-MS/MS and its Application in a Pharmacokinetic Study after the Oral Administration of <i>Polygoni cuspidati</i> Folium Capsules
Current Pharmaceutical Biotechnology Formulation Development of Nanoparticulate Periodontal Drug Delivery System of Metronidazole Benzoate with Combination Processing Method by Using Design of Experiment
Micro and Nanosystems Comparative Characterization of Experimental and Calculated Lipophilicity and Anti-Tumour Activity of Isochromanone Derivatives
Current Medicinal Chemistry