Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs

Author(s): Sara Richter , Manlio Palumbo .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 1 , 2003

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Abstract:

Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site, ii) miscellaneous molecules with unknown mechanism(s) of action, iii) inhibitors of upstream processes of regulation of the hTERT subunit, iiii) immunotherapy against immunogenic hTERT- derived peptides.

Keywords: telomerase, anticancer drug, telomerase inhibitor, htert, mock agents, htert subunit

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Article Details

VOLUME: 3
ISSUE: 1
Year: 2003
Page: [37 - 49]
Pages: 13
DOI: 10.2174/1389557033405511

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