Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups

Author(s): Jih Ru Hwu, Krishna S. Ethiraj, Gholam H. Hakimelahi.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 4 , 2003

Abstract:

This Review contains our recent studies on evaluation of biological activities associated with monocyclic β-lactams and bicyclic β-lactam antibiotics containing various heteroatoms. A series of bicyclic β-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These β-lactams exhibited enhanced antibacterial activity.

Keywords: bicyclic lactams, monocyclic lactams, lactam antibiotics, antibacterial activity

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2003
Page: [305 - 313]
Pages: 9
DOI: 10.2174/1389557033488132
Price: $58