Protein Therapy: In Vivo Protein Transduction by Polyarginine (11R) PTD and Subcellular Targeting Delivery

Author(s): Hideki Matsui, Kazuhito Tomizawa, Yun-Fei Lu, Masayuki Matsushita.

Journal Name:Current Protein & Peptide Science

Volume 4 , Issue 2 , 2003

Abstract:

Protein Therapy is a newly developed method, which allows proteins, peptides and biologically active compounds to penetrate across the plasma membrane of eukaryotic cells by a polyarginine (most efficiently by 11-arginine, 11R) protein transduction domain [1]. This method enables us to control the localization of targeted substances in subcellular compartments, such as the nuclei, mitochondria and post-synaptic density. The method is very efficient and applicable not only to c ultur ed ce lls but also to tissue slic e s and the whole a nimal. Bra in, hea r t, skeleta l muscle, liver, pancreas and lymphocytes are efficient target organs and tissues for Protein Therapy [1, 2]. The method is therefore a very useful strategy in the post-genomic era. In this mini-review, the development of Protein Therapy and its application for cancer cells and neuroscience study will be shown.

Keywords: Protein Therapy, Polyarginine, eukaryotic cells, 11-arginine, lymphocytes, neuroscience, cancer cells

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2003
Page: [151 - 157]
Pages: 7
DOI: 10.2174/1389203033487270
Price: $58

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