Current Protein & Peptide Science

Ben M. Dunn  
Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245


Guanidinium Rich Peptide Transporters and Drug Delivery

Author(s): Lee R. Wright, Jonathan B. Rothbard, Paul A. Wender.


The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variation and use of guanidinium based transporters to facilitate the uptake of various types of molecules into cells and tissues. Lead conjugates in this area are currently in clinical trials.

Keywords: Guanidinium, Drug Delivery, Rich Peptide Transporters

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Article Details

Year: 2003
Page: [105 - 124]
Pages: 20
DOI: 10.2174/1389203033487252
Price: $58