Direct Observation of Structure Transition of Donor-Acceptor Labeled Peptides: Temperature Dependence of Fluorescence Quenching Kinetics

Author(s): Wei Min, Lin Sun.

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 1 , 2003

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Abstract:

From the temperature dependence of fluorescence quenching kinetics, a novel temperaturesensitive structure transition was discovered in a donor-acceptor labeled peptides. Perfect agreement of related abrupt changes in a1,t1 andt2 gives strong support for the existence of this structure transition, which suggests it is possible to develop peptides that can be rapidly and reversibly switched between two structure states in response to temperature shift.

Keywords: electron transfer, fluorescence quenching, peptides, structure transition, molecular switches, labeled peptides

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2003
Page: [43 - 51]
Pages: 9
DOI: 10.2174/0929866033408255

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