Novel “Three-in-one” Peptide Device for Genetic Drug Delivery

Author(s): Jason Smith , Jesse Guidry , Pernilla Wittung-Stafshede .

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 1 , 2003

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Abstract:

We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.

Keywords: antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2003
Page: [1 - 7]
Pages: 7
DOI: 10.2174/0929866033408291

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