Novel “Three-in-one” Peptide Device for Genetic Drug Delivery

Jason      Smith; Jesse      Guidry; Pernilla      Wittung-Stafshede

Abstract

We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.

Keywords: antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery

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Protein & Peptide Letters

Title: Novel “Three-in-one” Peptide Device for Genetic Drug Delivery

Volume: 10 Issue: 1

Author(s): Jason Smith, Jesse Guidry and Pernilla Wittung-Stafshede

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Keywords: antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery

Abstract: We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.

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Smith Jason, Guidry Jesse and Wittung-Stafshede Pernilla, Novel “Three-in-one” Peptide Device for Genetic Drug Delivery, Protein & Peptide Letters 2003; 10 (1) . https://dx.doi.org/10.2174/0929866033408291