Recent Developments in the Medicinal Chemistry of NK2 Receptor Antagonists

Author(s): Anders Johansson.

Journal Name: Current Topics in Medicinal Chemistry

Volume 3 , Issue 12 , 2003

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Abstract:

The search for new NK2 receptor antagonists have resulted in the discovery of several different classes of compounds with promise to have clinical utility. Clearly, the first reported non-peptide NK2 receptor antagonist (SR- 48,968) has inspired a lot of effort in the area, but over the years other approaches have also been fruitful. These include optimisation of hits from random screening and modifying compounds with NK3 receptor antagonistic properties into selective NK2 receptor antagonists. This is also an area where cyclic peptides and derivatives have been extensively examined. So far, no NK2 receptor antagonist has reached the market, but several clinical trials are in progress.

Keywords: nk2 receptor antagonists, nk2 receptor, sr- 48,968), decapeptide, neurokinin a

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Article Details

VOLUME: 3
ISSUE: 12
Year: 2003
Page: [1436 - 1445]
Pages: 10
DOI: 10.2174/1568026033451835
Price: $58

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