Proliferative Activity Of Neokyotorphinrelated Hemoglobin Fragments In Cell Cultures

Author(s): Olga V. Sazonova, Elena Yu. Blishchenko, Olga A. Kalinina, Natalya S. Egorova, Andrei Yu. Surovoy, Marina M. Philippova, Andrei A. Karelin, Vadim T. Ivanov.

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 4 , 2003

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Abstract:

α-Hemoglobin fragments α-(133-141), α-(134-141), α-(135-141), α-(137-141), α-(134-140), α- (133-138), α-(134-140) and α-(137-138) stimulate L929 tumor cell proliferation, α-(134-141) being the most active. α-(134-141) stimulates proliferation of M3 melanoma cells, murine embryonic fibroblasts, primary cultures of red bone marrow and spleen cells. In L929 cells the effect of α-(134-141) is cell density independent; in M3 cells α-(137-141) and α-(134-141) are most active at density 10,000 cells / well (96 well plate) independently on FBS content.

Keywords: neokyotorphin, proliferation

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2003
Page: [386 - 395]
Pages: 10
DOI: 10.2174/0929866033478780
Price: $58

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