Imino-Sugar-Based Nucleosides

Author(s): Vern L. Schramm, Peter C. Tyler.

Journal Name: Current Topics in Medicinal Chemistry

Volume 3 , Issue 5 , 2003

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Abstract:

Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-Cnucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.

Keywords: imino-sugar-based, iminonucleosides, imino-c-nucleosides

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2003
Page: [525 - 540]
Pages: 16
DOI: 10.2174/1568026033452465
Price: $58

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