A Comparison of Calculated and Experimental Parameters as Sources of Structural Information: The Case of Lipophilicity-Related Descriptors

Author(s): Giulia Caron, Giuseppe Ermondi.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 8 , 2003

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Abstract:

This review is organized in three parts: firstly there is a general overview of recent developments in lipophilicity written to induce medicinal chemists to question what they want to obtain from this kind of study; secondly, the state-of-the-art of experimental and computational determination of log P is briefly reviewed; finally, some applications are discussed to illustrate how much information can be extracted from lipophilicity, and to highlight the difficulty of obtaining a reliable, general method to work with.

Keywords: log p, log d, partitioning system, clogp, distribution profile, folding

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Article Details

VOLUME: 3
ISSUE: 8
Year: 2003
Page: [821 - 830]
Pages: 10
DOI: 10.2174/1389557033487665
Price: $58

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