Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain

Author(s): Rosa Planells-Cases , Enrique Perez-Paya , Angel Messeguer , Cristina Carreno , Antonio Ferrer-Montiel .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 7 , 2003

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Abstract:

Pain is a complex disease that usually remains poorly treated or undertreated, especially the neuropathic pain caused by injury to the peripheral or central nervous system. Antagonists of the NMDA receptor complex have emerged as potential drugs for pain management. A strong case is being raised for noncompetitive or uncompetitive antagonists with low-to-moderate affinity and fast on / offset kinetics as drugs with good therapeutic profiles, because of their reduced side effects.

Keywords: excitatory activity, nerve damage, inflammation, ion channels, protein networks, uncompetitive antagonists, synaptic plasticity, drug discovery, pain killers

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Article Details

VOLUME: 3
ISSUE: 7
Year: 2003
Page: [749 - 756]
Pages: 8
DOI: 10.2174/1389557033487782
Price: $58

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