Recent Progress in the Design of Selectin Inhibitors

Author(s): Siri Ram Chhabra, Aisyah S. Abdul Rahim, Barrie Kellam.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 7 , 2003

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Abstract:

The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.

Keywords: selectins, sialyl lewis, adhesion molecules, antagonist, mimetics, inflammation

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Article Details

VOLUME: 3
ISSUE: 7
Year: 2003
Page: [679 - 687]
Pages: 9
DOI: 10.2174/1389557033487791
Price: $58

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