Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors

Author(s): Todd A. Houston, Joanne T. Blanchfield.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 7 , 2003

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Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.

Keywords: glycosidase inhibitors, glucosidase, mannosidase, galactosidase, sialidase, salacinol, cyclophellitol

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Article Details

Year: 2003
Page: [669 - 678]
Pages: 10
DOI: 10.2174/1389557033487827
Price: $58

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