Abstract
Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and other glycan-binding proteins. Moreover, the poly-Nacetyllactosamine chains in N-glycans have been found to promote tumor progression and metastasis. Poly-N-acetyllactosamine chains are synthesized by repeated alternating additions of Nacetylglucosamine and galactose, catalyzed by β-1,3-N-acetylglucosaminyltransferases (poly-N-acetyllactosamine synthase) and β-1,4-galactosyltransferases. This review describes the poly-N-acetyllactosamine assembling machinery and focuses on recent advances in the molecular cloning and characterization of poly-N-acetyllactosamine synthase gene families. Recent progress in revealing the biological functions of poly-N-acetyllactosamine structures by various approaches in vitro and in vivo using different model systems has also been summarized.
Keywords: poly-n-acetyllactosamine, 3-n-acetylglucosaminyltransferase, 4-galactosyltransferase
Current Protein & Peptide Science
Title: Why are Glycoproteins Modified by Poly-N-Acetyllactosamine Glycoconjugates?
Volume: 4 Issue: 1
Author(s): Dapeng Zhou
Affiliation:
Keywords: poly-n-acetyllactosamine, 3-n-acetylglucosaminyltransferase, 4-galactosyltransferase
Abstract: Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and other glycan-binding proteins. Moreover, the poly-Nacetyllactosamine chains in N-glycans have been found to promote tumor progression and metastasis. Poly-N-acetyllactosamine chains are synthesized by repeated alternating additions of Nacetylglucosamine and galactose, catalyzed by β-1,3-N-acetylglucosaminyltransferases (poly-N-acetyllactosamine synthase) and β-1,4-galactosyltransferases. This review describes the poly-N-acetyllactosamine assembling machinery and focuses on recent advances in the molecular cloning and characterization of poly-N-acetyllactosamine synthase gene families. Recent progress in revealing the biological functions of poly-N-acetyllactosamine structures by various approaches in vitro and in vivo using different model systems has also been summarized.
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Cite this article as:
Zhou Dapeng, Why are Glycoproteins Modified by Poly-N-Acetyllactosamine Glycoconjugates?, Current Protein & Peptide Science 2003; 4 (1) . https://dx.doi.org/10.2174/1389203033380304
DOI https://dx.doi.org/10.2174/1389203033380304 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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