Abstract
7-keto-Δ5-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Δ5-steroids. These methods and the biological evaluation of the main oxidized Δ5-steroids are summarized.
Keywords: 7-keto-, allylic oxidation, 7-keto-cholesterol, 7-keto-dhea, anticancer activity, aromatase inhibitors, apoptosis
Mini-Reviews in Medicinal Chemistry
Title: 7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest
Volume: 3 Issue: 6
Author(s): E. S. Arsenou, M. A. Fousteris, A. I. Koutsourea and S. S. Nikolaropoulos
Affiliation:
Keywords: 7-keto-, allylic oxidation, 7-keto-cholesterol, 7-keto-dhea, anticancer activity, aromatase inhibitors, apoptosis
Abstract: 7-keto-Δ5-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Δ5-steroids. These methods and the biological evaluation of the main oxidized Δ5-steroids are summarized.
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Cite this article as:
Arsenou S. E., Fousteris A. M., Koutsourea I. A. and Nikolaropoulos S. S., 7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487953
DOI https://dx.doi.org/10.2174/1389557033487953 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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