7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest

Author(s): E. S. Arsenou, M. A. Fousteris, A. I. Koutsourea, S. S. Nikolaropoulos.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 3 , Issue 6 , 2003

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Abstract:

7-keto-Δ5-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Δ5-steroids. These methods and the biological evaluation of the main oxidized Δ5-steroids are summarized.

Keywords: 7-keto-, allylic oxidation, 7-keto-cholesterol, 7-keto-dhea, anticancer activity, aromatase inhibitors, apoptosis

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2003
Page: [557 - 567]
Pages: 11
DOI: 10.2174/1389557033487953
Price: $58

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