The Role Of Tyrosine Residues In The Rna N-Glycosidase Activity Of Cinnamomin A-Chain

Author(s): Hong Xu, Wang-Yi Liu.

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 5 , 2003

Become EABM
Become Reviewer


Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA Nglycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by NAI. It is proposed that tyrosine residues are involved in the active site of CTA and they are crucial in recognition and binding of ribosomal RNA. Tryptophan residues of CTA are also studied by NBS modification.

Keywords: chemical modification, cinnamomin, ribosome-inactivating protein, rna n-glycosidase, tryptophan residue, tyrosine residue

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2003
Page: [503 - 509]
Pages: 7
DOI: 10.2174/0929866033478771
Price: $58

Article Metrics

PDF: 1