Factors Determining The Efficacy Of Alphahelical Antimicrobial Peptides

Author(s): Sarah R. Dennison, Frederick Harris, David A. Phoenix.

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 5 , 2003

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Abstract:

A database of α-helical antimicrobial peptides (AMP) was established and their minimum inhibitory concentrations (MIC) were compared with their physiochemical characteristics in an attempt to establish those features that determine efficacy. There is no significant difference in AMP sensitivity between Gram-positive and Gram-negative bacteria but fungi did require higher concentrations to achieve the same degree of growth inhibition. For antibacterial peptides there appears to be a positive correlation between MIC and hydrophobic arc size and a negative correlation between MIC and net charge.

Keywords: Antimicrobial Peptides, Gram-negative bacteria, fungi, hydrophobic arc

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2003
Page: [497 - 502]
Pages: 6
DOI: 10.2174/0929866033478663
Price: $58

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