A Sequence Function Reveals New Features In β-Protein Folding

Author(s): Hui Shao, Zong-Hao Zeng.

Journal Name: Protein & Peptide Letters

Volume 10 , Issue 5 , 2003

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Abstract:

When amino acid residues are represented by parameters describing their side chain lengths and polarities, a sequence function defined as the sum of the first two sequence autocorrelation functions is found to be negatively and linearly correlated with the logarithms of folding rates of β-proteins. The new function reveals new features in β-protein folding: larger residues slow down the folding while alternative distribution of polar-non-polar residues accelerates the folding.

Keywords: Protein, polar-non-polar residues

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2003
Page: [435 - 439]
Pages: 5
DOI: 10.2174/0929866033478690
Price: $58

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