Isoquinoline Alkaloids from Duguetia Vallicola Stem Bark with Antiplasmodial Activity

Author(s): E. Perez, J. Saez, S. Blair, X. Franck, B. Figadere.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Abstract:

Duguevalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids, cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), were isolated and characterized from Duguetia vallicola stems. Structural elucidation of these compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4) exhibited antiplasmodial activity against Plasmodium falciparum.

Keywords: isoquinoline alkaloids, duguetia vallicola, annonaceae, antiplasmodial

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [102 - 104]
Pages: 3
DOI: 10.2174/1570178043488743

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