The Application of Quantitative Analytical Constructs for Chemistry Optimization, Monomer Rehearsal and Reactivity Prediction in Solid Phase Library Synthesis

Author(s): Nigel J. Parr , Stephen C. McKeown , Mika K. Lindvall , Olivier E. Lorthioir , Miles S. Congreve , Stephen P. Watson .

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Abstract:

The use of quantitative dual linker analytical constructs for the high-throughput generation of solid phase reaction data is described. This methodology can be applied to chemistry optimization, monomer rehearsal and monomer reactivity prediction as a tool to aid the production of solid phase compound libraries.

Keywords: analytical methods, combinatorial chemistry, mass spectrometry, solid-phase synthesis

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [87 - 92]
Pages: 6
DOI: 10.2174/1570178043488653

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