Preparations of the symmetric bisquaternary oximes - 1,4-bis(2-hydroxyiminomethypyridinium) butane dibromide and 1,3-bis(2-hydroxyiminomethypyridinium)propane dibromide, and their abilities to reactivate cyclosarin-inhibited acetylcholinesterase are described. Common reactivator (pralidoxime) was used as a standard for comparison of the reactivation efficacy. The first oxime seems to be very good reactivator of cyclosarin-inhibited acetylcholinesterase.
Keywords: oximes, reactivation, acetylcholinesterase, cyclosarin
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