Catalytic, Asymmetric Synthesis of Cyanohydrin Esters: The Effect of Anhydride Structure on Enantioselectivity

Author(s): Y. N. Belokon, P. Carta, M. North.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Abstract:

A bimetallic titanium(salen) complex has been shown to catalyse the asymmetric addition of potassium cyanide to aldehydes in the presence of a range of anhydrides, leading to cyanohydrin esters. Linear aliphatic anhydrides (acetic and propionic) gave products with higher enantiomeric purity than those obtained using pivalic or benzoic anhydrides.

Keywords: cyanohydrin, catalyst, ester, titanium, salen

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [81 - 83]
Pages: 3
DOI: 10.2174/1570178043488617

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