Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

Author(s): E. Kerouredan, M. Prakesch, D. Gree, R. Gree.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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The first total synthesis of the 13,13 difluoro analog of 13 HODE, via the novel fluorinated synthons (5) and (2), is reported. The key advantages of using a propargylic route for the introduction of the gem difluoro moiety are highlighted below.

Keywords: fluorine, dast, 13 hode, lipids

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Article Details

Year: 2004
Page: [78 - 80]
Pages: 3
DOI: 10.2174/1570178043488662

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