Abstract
In the search for new chelation therapy drugs for the treatment of metal intoxications, some new polyphosphonated chelating ligands have been synthesized. They were obtained by means of an Arbuzov reaction followed by addition of the corresponding dialkylphosphite. The regioselective dealkylation was then carried out by using trimethylsilyl halide.
Keywords: tetraphosphonate, chelating agents, restrained geometry, partial deprotection
Letters in Organic Chemistry
Title: Synthesis of New Ligands Derived from Polyphosphonates Partial Esters
Volume: 1 Issue: 1
Author(s): Pascale Even, Erwann Guenin, Mounya Benramdame, Patricia Quidu, Driss El Manouni and Marc Lecouvey
Affiliation:
Keywords: tetraphosphonate, chelating agents, restrained geometry, partial deprotection
Abstract: In the search for new chelation therapy drugs for the treatment of metal intoxications, some new polyphosphonated chelating ligands have been synthesized. They were obtained by means of an Arbuzov reaction followed by addition of the corresponding dialkylphosphite. The regioselective dealkylation was then carried out by using trimethylsilyl halide.
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Cite this article as:
Even Pascale, Guenin Erwann, Benramdame Mounya, Quidu Patricia, Manouni El Driss and Lecouvey Marc, Synthesis of New Ligands Derived from Polyphosphonates Partial Esters, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488563
DOI https://dx.doi.org/10.2174/1570178043488563 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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