Synthesis of New Ligands Derived from Polyphosphonates Partial Esters

Author(s): Pascale Even, Erwann Guenin, Mounya Benramdame, Patricia Quidu, Driss El Manouni, Marc Lecouvey.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Abstract:

In the search for new chelation therapy drugs for the treatment of metal intoxications, some new polyphosphonated chelating ligands have been synthesized. They were obtained by means of an Arbuzov reaction followed by addition of the corresponding dialkylphosphite. The regioselective dealkylation was then carried out by using trimethylsilyl halide.

Keywords: tetraphosphonate, chelating agents, restrained geometry, partial deprotection

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [75 - 77]
Pages: 3
DOI: 10.2174/1570178043488563

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