A General Access to 2-Silylthiazolidines and Their Reactions Under Fluoride Ion Conditions

Author(s): Antonella Capperucci, Alessandro Degl'Innocenti, Tiziano Nocentini, Alessandro Mordini, Simona Biondi, Francesca Dini.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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2-Trimethylsilylthiazolidines were readily obtained through reaction of aminoethanethiol with (bromomethoxymethyl)trimethylsilane and efficiently N-functionalized with a variety of protecting groups. Such N-protected thiazolidines can then be satisfactorily reacted with several organic electrophiles under fluoride ion conditions, with a clean transfer of the thiazolidine moiety, to afford good yields of 2- functionalized heterocycles.

Keywords: Silylthiazolidines, bromomethoxymethyl, thiazolidines

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Article Details

Year: 2004
Page: [55 - 58]
Pages: 4
DOI: 10.2174/1570178043488815

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