An Efficient Synthesis of Hexahydro Oxaisoindolo[2,1-a]Quinoline Derivatives via the Diels-Alder Reactions

Author(s): Vladimir V. Kouznetsov, Fedor I. Zubkov, Uriel Mora Cruz, Leonid G. Voskressensky, Leonor Y. Vargas Mendez, Luis Astudillo, Elena E. Stashenko.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Abstract:

The straightforward synthesis of new carboxylic acids with hexahydro-oxaisoindolo[2,1- a]quinoline core from the 2,4-disustituted 1,2,3,4-tetrahydroquinolines bearing a furan fragment via the intramolecular Diels-Alder reaction has been proposed. It was demonstrated that synthesis of key precursors can be realized with excellent level of diastereoselectivity either by imino-Diels-Alder reaction or multicomponent condensation approach.

Keywords: Hexahydro Oxaisoindolo[2,1-a]Quinoline, diastereoselectivity, 2,4-disustituted, tetrahydroquinolines

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2004
Page: [37 - 39]
Pages: 3
DOI: 10.2174/1570178043488572

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