Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity

Author(s): Kazunobu Toshima, Yoko Nakajima, Yutaka Maeda, Shuichi Matsumura.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 1 , 2004

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Novel anthraquinone-carbohydrate hybrids were designed and synthesized as artificial DNA photocleavers. They were found to show high DNA cleaving activity under irradiation with a long wavelength UV light without any additives and also exhibited selective cytotoxicity against HeLa S3 cancer cells with the photoirradiation.

Keywords: anthraquinone, carbohydrate, photoirradiation, dna cleavage, cancer cells, cytotoxicity

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Article Details

Year: 2004
Page: [31 - 33]
Pages: 3
DOI: 10.2174/1570178043488581

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