Abstract
This review provides an introduction to three of the most well-developed solvent replacement strategies currently under investigation for synthetic chemistry: Ionic liquids, fluorous phase techniques, and supercritical carbon dioxide. They are all fascinating reaction media, and have considerable potential for use in pharmaceutical synthesis. However, this has to be balanced with problems and limitations of the new methods. This review aims to provide an overall account of recent advances in the use of unusual media for synthetic chemistry, with an emphasis on highlighting potential benefits, but also limitations, of each of the methods described.
Keywords: pharmaceutical synthesis, carbondioxide, Ionic liquids, solvent
Current Topics in Medicinal Chemistry
Title: Reactions in Unusual Media
Volume: 4 Issue: 7
Author(s): Daniel Clarke, Mohammed A. Ali, Anthony A. Clifford, Andrew Parratt, Paul Rose, Dominik Schwinn, Willi Bannwarth and Christopher M. Rayner
Affiliation:
Keywords: pharmaceutical synthesis, carbondioxide, Ionic liquids, solvent
Abstract: This review provides an introduction to three of the most well-developed solvent replacement strategies currently under investigation for synthetic chemistry: Ionic liquids, fluorous phase techniques, and supercritical carbon dioxide. They are all fascinating reaction media, and have considerable potential for use in pharmaceutical synthesis. However, this has to be balanced with problems and limitations of the new methods. This review aims to provide an overall account of recent advances in the use of unusual media for synthetic chemistry, with an emphasis on highlighting potential benefits, but also limitations, of each of the methods described.
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Cite this article as:
Clarke Daniel, Ali A. Mohammed, Clifford A. Anthony, Parratt Andrew, Rose Paul, Schwinn Dominik, Bannwarth Willi and Rayner M. Christopher, Reactions in Unusual Media, Current Topics in Medicinal Chemistry 2004; 4 (7) . https://dx.doi.org/10.2174/1568026043451096
DOI https://dx.doi.org/10.2174/1568026043451096 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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