Steps towards Phage Display Libraries with an Extended Amino Acid Repertoire

Title: Steps towards Phage Display Libraries with an Extended Amino Acid Repertoire

Volume: 1 Issue: 2

Author(s): M. Bjorklund and E. Koivunen

Affiliation:

Keywords: combinatorial chemistry, phage display, peptide, unnatural amino acid

Abstract: To increase the peptide diversity of phage display libraries, we examined the incorporation of amino acid analogues into bacteriophage using auxotrophic E. coli strains. Fluorinated tryptophan analogues and norleucine were efficiently incorporated into phage particles. Phage display of unnatural amino acids may have wide applications in the drug discovery process.

Cite this article as:

Bjorklund M. and Koivunen E., Steps towards Phage Display Libraries with an Extended Amino Acid Repertoire, Letters in Drug Design & Discovery 2004; 1 (2) . https://dx.doi.org/10.2174/1570180043485572