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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

Author(s): M. Brinkman, J. Walter, I. Jennes, M. Neugebauer, W. Bertling, S. Grein, M. Thies, M. Weigand, T. Beyer and M. Herrmann

Volume 1, Issue 2, 2004

Page: [137 - 147] Pages: 11

DOI: 10.2174/1570180043485545

Price: $65

Abstract

Subcutaneous vaccination of mice with chimerical polyomavirus-likeparticles consisting of a VP1-ovalbumin (OVA252-270) fusion protein induced immunodominant H-2Kb-restricted and OVA257-264-specific CD8 T cells in mice. Single immunisations with VP1-OVA252-270 capsoids failed to have beneficial effects on tumour protection, only double vaccinations in weekly intervals protected mice from lethal MO5 melanoma challenge.

Keywords: peptide delivery, cell-mediated immunity, virus-like-particles, tumour vaccination


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