Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity
Subcutaneous vaccination of mice with chimerical polyomavirus-likeparticles consisting of a VP1-ovalbumin (OVA252-270) fusion protein induced immunodominant H-2Kb-restricted and OVA257-264-specific CD8 T cells in mice. Single immunisations with VP1-OVA252-270 capsoids failed to have beneficial effects on tumour protection, only double vaccinations in weekly intervals protected mice from lethal MO5 melanoma challenge.
Keywords: peptide delivery, cell-mediated immunity, virus-like-particles, tumour vaccination
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