Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

Author(s): M. Brinkman, J. Walter, I. Jennes, M. Neugebauer, W. Bertling, S. Grein, M. Thies, M. Weigand, T. Beyer, M. Herrmann.

Abstract:

Subcutaneous vaccination of mice with chimerical polyomavirus-likeparticles consisting of a VP1-ovalbumin (OVA252-270) fusion protein induced immunodominant H-2Kb-restricted and OVA257-264-specific CD8 T cells in mice. Single immunisations with VP1-OVA252-270 capsoids failed to have beneficial effects on tumour protection, only double vaccinations in weekly intervals protected mice from lethal MO5 melanoma challenge.

Keywords: peptide delivery, cell-mediated immunity, virus-like-particles, tumour vaccination

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [137 - 147]
Pages: 11
DOI: 10.2174/1570180043485545
Price: $58