Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Thalidomide as an Antiangiogenic Drug in the Treatment of Multiple Myeloma

Author(s): Domenico Ribatti, Angelo Vacca.

Abstract:

Experimental studies have demonstrated that thalidomide, a drug developed as a sedative, has antitumoral properties. Its broad spectrum of actions besides its antiangiogenic potential, includes immunomodulatory properties, antiinflammatory actions and direct effect on tumor cells and their microenvironment. Multiple myeloma is so far the most responsive malignancy.

Keywords: angiogenesis, antiangiogenesis, multiple myeloma, thalidomide

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [135 - 136]
Pages: 2
DOI: 10.2174/1570180043485491
Price: $58