Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Diverse Peptidyl Privileged Structures as Potent Somatostatin Receptor Ligands

Author(s): Alexander Pasternak, Yanping Pan, Ralph T. Mosley, Susan P. Rohrer, Elizabeth T. Birzin, James Schaeffer, Arthur A. Patchett, Lihu Yang.

Abstract:

This report describes the evaluation of a wide range of structurally diverse “privileged structures”, either amines or acids, linked via urea and amide connections, to the key dipeptide D-Trp-Lys-OMe. This led to the discovery of a collection of potent and structurally distinct SSTR2 ligands in both the amide and urea series. The 4- (benzimidazolone)-piperidine linked SSTR2 agonist (8) is highlighted.

Keywords: peptidyl privileged structures, somatostatin receptor ligands, d-trp-lys-ome, (benzimidazolone)-piperidine

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [121 - 125]
Pages: 5
DOI: 10.2174/1570180043485563
Price: $58