Abstract
The interaction of seventeen heteroarenium salts with the enzyme acetylcholinesterase was investigated using in vitro experiments. Rat brains were used as a source of the enzyme. All compounds involved in this study were found to be competitive acetylcholinesterase inhibitors. 10-methyl-acridinium iodide seems to be the most potent acetylcholinesterase inhibitor.
Keywords: acetylcholinesterase, heteroarenium salts, inhibition, reactivation
Letters in Drug Design & Discovery
Title: Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase
Volume: 1 Issue: 2
Author(s): Kamil Kuca, Jiri Cabal, Jiri Patocka and Vlastimil Dohnal
Affiliation:
Keywords: acetylcholinesterase, heteroarenium salts, inhibition, reactivation
Abstract: The interaction of seventeen heteroarenium salts with the enzyme acetylcholinesterase was investigated using in vitro experiments. Rat brains were used as a source of the enzyme. All compounds involved in this study were found to be competitive acetylcholinesterase inhibitors. 10-methyl-acridinium iodide seems to be the most potent acetylcholinesterase inhibitor.
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Cite this article as:
Kuca Kamil, Cabal Jiri, Patocka Jiri and Dohnal Vlastimil, Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase, Letters in Drug Design & Discovery 2004; 1 (2) . https://dx.doi.org/10.2174/1570180043485509
DOI https://dx.doi.org/10.2174/1570180043485509 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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