Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase

Author(s): Kamil Kuca, Jiri Cabal, Jiri Patocka, Vlastimil Dohnal.

Abstract:

The interaction of seventeen heteroarenium salts with the enzyme acetylcholinesterase was investigated using in vitro experiments. Rat brains were used as a source of the enzyme. All compounds involved in this study were found to be competitive acetylcholinesterase inhibitors. 10-methyl-acridinium iodide seems to be the most potent acetylcholinesterase inhibitor.

Keywords: acetylcholinesterase, heteroarenium salts, inhibition, reactivation

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [97 - 100]
Pages: 4
DOI: 10.2174/1570180043485509
Price: $58