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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 4
ISSUE: 5
DOI: 10.2174/1389557043403800      Price:  $58









Antiviral Activity Of Ribosome Inactivating Proteins In Medicine

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Author(s): Bijal A. Parikh and Nilgun E. Tumer
Pages 523-543 (21)
Abstract:
Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs. Antiviral activity of RIPs is summarized here in light of their novel activities and recent developments in the field.
Keywords:
antiviral activity, ribosome inactivating proteins, rrna, rips
Affiliation:
Biotechnology Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520, USA