Mini-Reviews in Medicinal Chemistry


Antiviral Activity Of Ribosome Inactivating Proteins In Medicine

Author(s): Bijal A. Parikh and Nilgun E. Tumer

Affiliation: Biotechnology Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520, USA

Keywords: antiviral activity, ribosome inactivating proteins, rrna, rips


Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs. Antiviral activity of RIPs is summarized here in light of their novel activities and recent developments in the field.

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Article Details

Page: [523 - 543]
Pages: 21
DOI: 10.2174/1389557043403800