Mini-Reviews in Medicinal Chemistry

Back

Ribosome-Inactivating Proteins: Entry into Mammalian Cells and Intracellular Routing

Author(s): Lynne M. Roberts, J. Michael Lord.

Abstract:

To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.

Keywords: ricin, depurination, ribosome, endoplasmic reticulum, retograde transport, retro-translocation

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 4
ISSUE: 5
Year: 2004
Page: [505 - 512]
Pages: 8
DOI: 10.2174/1389557043403846
Price: $58