Ribosome-Inactivating Proteins: Entry into Mammalian Cells and Intracellular Routing
Lynne M. Roberts,
J. Michael Lord.
To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.
Keywords: ricin, depurination, ribosome, endoplasmic reticulum, retograde transport, retro-translocation
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