Genetics of Ribosome-Inactivating Proteins

Author(s): Martin R. Hartley, J. Michael Lord.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 5 , 2004

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Abstract:

Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They encompass single enzymatic chains, heterodimeric toxic lectins and related agglutinins. Plants commonly produce several RIP isoforms encoded by multi-gene families. The toxic lectins possess adaptations related to their cytotoxic role.

Keywords: ribosome-inactivating protein, ricin, pokeweed antiviral protein, rna n-glycosidase

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2004
Page: [487 - 492]
Pages: 6
DOI: 10.2174/1389557043403828
Price: $58

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